Hybrid Matter is a research-based project and pedagogical framework that merges sustainable art practices, new media, and bio-design. The project originated as a response to plastic pollution, particularly within artistic production, where synthetic materials often contradict ecological awareness. In addressing this issue, Hybrid Matter explores biodegradable alternatives and hybrid processes that connect digital fabrication, biological growth, and environmental systems. The presentation introduces the conceptual and technical development of Hybrid Matter and its central tool, the MycoPrinter—a custom-built, open-source 3D printer designed to print with biomaterials such as coffee grounds, soil, clay, and cardboard. Once printed, these substrates are inoculated with living organisms—fungi, slime molds, or plants—transforming static forms into living, evolving sculptures. By embracing randomness, machine error, and biological agency, the project challenges industrial notions of precision and permanence, proposing new ways to think about authorship, decay, and collaboration across species. As both an artistic practice and teaching model, Hybrid Matter establishes a cross-disciplinary framework that integrates art, science, and sustainability. Participants employ tools like slit scanning, photogrammetry, and basic 3D modeling to map and visualize media ecologies across real and virtual spaces. The resulting works reflect both local material histories and the potential of regenerative design. Ultimately, Hybrid Matter aims to transform the ways artists and communities engage with technology and the environment. It positions art-making as a form of CARE—care for materials, communities, and the more-than-human world—inviting participants to imagine creative practices that are responsive, collaborative, and ecologically attuned.